QSAR STUDY ON THE HISTAMINE (H3) RECEPTOR ANTAGONISTS USING THE GENETIC ALGORITHM: MULTI PARAMETER LINEAR REGRESSION

QSAR study on the histamine (H3) receptor antagonists using the genetic algorithm: Multi parameter linear regression

A quantitative structure activity relationship (QSAR) model has been produced for predicting antagonist potency of biphenyl derivatives as human histamine (H3) receptors.The molecular structures of the compounds are Champagne Saucer numerically represented by various kinds of molecular descriptors.The whole data set was divided into training and te

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In vivo screening reveals interactions between Drosophila Manf and genes involved in the mitochondria and the ubiquinone synthesis pathway

Abstract Background Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) and Cerebral Dopamine Neurotrophic Factor (CDNF) form an evolutionarily conserved family of neurotrophic factors.Orthologues for MANF/CDNF are the only neurotrophic factors as yet identified in invertebrates with conserved amino acid sequence.Previous studies indicate th

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The Past and Future of Nursing Research

The past three decades have witnessed a remarkable growth in nursing science development.In both Korea and the United States, Jacket nurse scientists are poised to address important issues related to the prevention and management of significant health care problems.The need for greater nursing science development in the areas of self management, ge

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